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为了减少病人术后的疼痛,我们在使用药剂方面曾进行了一些研究,根据文献记载,许多药物如乙醇,酚,奎宁,乌拉坦等都有局部麻醉作用,其中尤以奎宁与乙醇的注射,可使神经机能麻痹至几个星期至几个月之久,但在麻痹之前先出现强烈的刺激作用,甚至能损害局部组织,故不宜用于临床,但当减低其浓度或加入其他药物时,则可减低其对局部组织的刺激作用,如复方奎宁注射液中含有乌拉坦,当然浓度降低局部麻醉作用也相应减弱,假使加入盐酸普鲁卡因使其发挥协同作用则很可能得到一种无刺激性的长效局部麻醉药。我们根据上述资料,拟定了下列处方,名为复方盐酸普鲁卡因注射液,使用效果满意,特作介绍。
In order to reduce the patient’s pain after surgery, we have conducted some studies on the use of agents, according to the literature, many drugs such as ethanol, phenol, quinine, urethane and other local anesthesia, especially quinine and ethanol Injection can paralyze the nerve function to a few weeks to several months, but before the paralysis appeared strong stimulus, or even damage to local tissue, it is not suitable for clinical, but when reducing its concentration or adding other drugs , It can reduce its stimulation of local tissue, such as compound quinine injection containing urethane, of course, reduce the concentration of local anesthesia is also a corresponding decrease, if the addition of procaine hydrochloride to synergies it is likely to be A non-irritating long-acting local anesthetic. We based on the above information, the formulation of the following prescriptions, known as compound procaine hydrochloride injection, the use of satisfactory results, special presentation.