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生长激素(growth hormone,GH)是腺垂体合成和分泌的重要激素之一,大部分通过其介质胰岛素样生长因子-1(insu lin-like growth factors-1,IGF-1)发挥作用。GH/IGF-1对心血管系统具有促进心肌生长,增强心肌收缩力等特殊效应。因而在心力衰竭的治疗中有着重要的价值,现对GH/IGF-1治疗心力衰竭的可能机制作一综述。
Growth hormone (GH) is one of the important hormones in the synthesis and secretion of the pituitary gland, and most of them play a role through its mediator insulin-like growth factors-1 (IGF-1). GH / IGF-1 has special effects on the cardiovascular system to promote myocardial growth and enhance myocardial contractility. Therefore, it is of great value in the treatment of heart failure. The possible mechanism of GH / IGF-1 in treating heart failure is reviewed.