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目的探讨硝苯地平治疗轻中度高血压患者的临床疗效及药理分析。方法选取我院2013年7月至2014年5月确诊的轻中度高血压患者70例,随机分为观察组与对照组,各35例。观察组患者服用硝苯地平控释片治疗,对照组患者服用硝苯地平片治疗,比较两组患者的临床效果。结果治疗前,两组患者的收缩压(SBP)与舒张压(DBP)值比较,差异无统计学意义(P>0.05);治疗后,观察组患者的SBP与DBP变化明显,血压下降明显优于对照组;且观察组患者总有效率为94.3%,明显优于对照组的82.9%,差异均有统计学意义(均P<0.05)。结论硝苯地平控释片治疗轻中度高血压降压效果明显,且安全性好,不良反应少。
Objective To investigate the clinical efficacy and pharmacological analysis of nifedipine in patients with mild to moderate hypertension. Methods Seventy patients with mild to moderate essential hypertension diagnosed in our hospital from July 2013 to May 2014 were randomly divided into observation group and control group with 35 cases each. Patients in the observation group were treated with nifedipine controlled release tablets and patients in the control group were treated with nifedipine tablets. The clinical effects of the two groups were compared. Results Before treatment, there was no significant difference in SBP and DBP between the two groups (P> 0.05). After treatment, the SBP and DBP in the observation group changed significantly and the blood pressure decreased significantly In the control group, the total effective rate in the observation group was 94.3%, which was significantly better than that in the control group (82.9%) (all P <0.05). Conclusion Nifedipine GITS has obvious antihypertensive efficacy in mild to moderate hypertension with good safety and few adverse reactions.