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目的探讨葛根素对急性心肌梗死患者梗死面积及脂肪酸代谢、炎症反应及斑块稳定性的影响。方法 6 1例急性心肌梗死患者随机分为对照组 (30例 )和葛根素组 (31例 ) ,两组均予常规治疗 ,葛根素组加用葛根素 5 0 0mg/d ,疗程 2周。测定治疗前后血浆游离脂肪酸、基质金属蛋白酶 9(matrixmetalloproteinases 9,MMP 9)、C 反应蛋白水平及用IdekerQRS记分法测定梗死面积。结果治疗前血浆自由脂肪酸、MMP 9、C 反应蛋白与梗死面积呈正相关 (r =0 4 3、0 4 2、0 39,P <0 0 1) ;与治疗前比较 ,葛根素组自由脂肪酸、MMP 9及C 反应蛋白分别降低 30 %、4 1%、2 3% ,梗死面积明显缩小 (P <0 0 1) ,对照组无明显变化 (P >0 0 5 )。结论葛根素治疗可明显缩小急性心肌梗死面积 ,可能与降低血浆自由脂肪酸、抑制炎症及稳定动脉粥样硬化斑块有关
Objective To investigate the effects of puerarin on infarct size, fatty acid metabolism, inflammation and plaque stability in patients with acute myocardial infarction. Methods Sixteen patients with acute myocardial infarction were randomly divided into control group (n = 30) and puerarin group (n = 31). Both groups were given routine treatment. Puerarin group received Puerarin 500 mg daily for 2 weeks. The level of plasma free fatty acid, matrix metalloproteinase 9 (MMP 9) and C-reactive protein were measured before and after treatment. The infarct size was measured by IdekerQRS scoring system. Results Before treatment, the levels of free fatty acids, MMP-9 and CRP were positively correlated with infarct size (r = 0 4 3,0 4 2,039, P 0 01). Compared with those before treatment, the levels of free fatty acids, MMP-9 and C-reactive protein decreased by 30%, 41%, 23%, infarct size significantly reduced (P <0 01), while there was no significant change in the control group (P 0 05). Conclusion Puerarin treatment can significantly reduce the area of acute myocardial infarction may be related to lower plasma free fatty acids, inhibition of inflammation and stable atherosclerotic plaque