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很久以前,就已发现牛胎血清中存在着生后不久即消失的蛋白质。以后在人胎血清中发现有特异的蛋白质。1963年Abelev等报道原发性肝癌之小白鼠血中也出现其胎鼠特有之蛋白质。之后定名为甲种胎儿蛋白(α-feto protein略称AFP),主要应用在内科疾病诊断上。以往对本蛋白的测定常常使用的琼脂扩散法和电泳法,不能检查1微克/毫升,以下之AFP,故在妇产科方面不大使用。近年来,由于用放射免疫法(RIA),可定量达毫微克/毫升水
Long ago, it has been found in fetal bovine serum that disappears shortly after the protein. After the fetal serum found in the specific protein. In 1963, Abelev et al. Reported that fetal rat-specific proteins also appeared in the blood of mice with primary liver cancer. Later named a type of fetal protein (α-feto protein referred to as AFP), mainly used in the diagnosis of internal medicine. In the past, the agar diffusion method and the electrophoresis method commonly used for the determination of this protein were not able to check AFP of 1 μg / ml or less, so they were not used in obstetrics and gynecology. In recent years, due to radioimmunoassay (RIA), up to nanograms / milliliter of water can be quantified