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为探讨ｃ－ｅｒｂＢ－２基因蛋白和ＰＣＮＡ在膀胱癌及肾盂癌中的表达及意义。作者应用免疫组化技术研究４７例膀胱移行细胞癌和１８例肾盂移行细胞癌与ｃ－ｅｒｂＢ－２基因蛋白和ＰＣＮＡ的关系。结果显示ｃ－ｅｒｂＢ－２蛋白表达与膀胱癌和肾盂癌的分级和分期有关，ＰＣＮＡ增殖指数随肿瘤分级的上升而增高，与肿瘤的分期也有关系，但ｃ－ｅｒｂＢ－２和ＰＣＮＡ两者间无明显关系。结果表明ｃ－ｅｒｂＢ－２和ＰＣＮＡ对膀胱癌和肾盂癌的生物学行为和预后评估具有重要意义。
To investigate the expression and significance of c-erbB-2 gene protein and PCNA in bladder cancer and renal pelvis and cancer. The authors used immunohistochemistry to study the relationship between c-erbB-2 gene protein and PCNA in 47 cases of transitional cell carcinoma of the bladder and 18 cases of renal pelvis transitional cell carcinoma. The results showed that the expression of c-erbB-2 was related to the grade and stage of bladder cancer and renal pelvis cancer. The proliferation index of PCNA increased with the increase of tumor grade, which was also related to the stage of the tumor. However, the relationship between c-erbB-2 and PCNA No obvious relationship. The results show that c-erbB-2 and PCNA for bladder cancer and renal pelvis cancer biological behavior and prognostic evaluation of great significance.