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目的探讨代谢综合征(MS)患者血糖、血脂和血压控制达标后对血尿酸(SUA)的影响。方法新诊断MS患者414例,予降糖、调脂和降压达标治疗,对SUA不直接干预;观察达标治疗前后SUA变化,并进行相关分析。结果血糖、血脂和血压达标治疗后,MS患者SUA水平明显降低(P<0.01),高尿酸血症(HUA)发病率明显下降(P<0.01);治疗前后SUA变化差值与空腹胰岛素、甘油三酯、胰岛素抵抗指数的变化值呈正相关(P<0.01)。结论 MS患者控制血糖、血脂和血压可以显著降低SUA水平,一定程度上减少HUA的发病率。
Objective To investigate the effect of blood sugar, blood lipids and blood pressure on serum uric acid (SUA) after metabolic syndrome (MS) patients reach the standard. Methods 414 newly diagnosed MS patients were treated with hypoglycemic, lipid-lowering and antihypertensive treatment without any direct intervention to SUA. The changes of SUA before and after the standard treatment were observed and analyzed. Results After treatment with blood glucose, blood lipids and blood pressure, the SUA level was significantly decreased (P <0.01) and the incidence of hyperuricemia (HUA) was significantly decreased in MS patients (P <0.01). The difference of SUA before and after treatment was positively correlated with fasting insulin, Triglycerides, insulin resistance index changes were positively correlated (P <0.01). Conclusion MS patients control blood sugar, blood lipids and blood pressure can significantly reduce SUA levels, to a certain extent, reduce the incidence of HUA.