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目的 :观察中晚期胃肠道癌腹腔 +全身序贯化疗的增效作用及毒副反应。方法 :应用 5 - Fu+HCPT+DDP腹腔内灌注结合 L V+5 - Fu+HCPT+DDP全身化疗 ,并随机选择具可比性同类患者单纯全身化疗 (后者 )作对照 ,连续 3周期以上评定疗效并记录毒副反应。结果 :观察组 4 1例中完全缓解 (CR) 2例 ,部分缓解 (PR) 2 0例 ,总有效率 5 3.7% ;对照组 38例 CR0例 ,PR11例 ,总有效率 2 8.9% ,差异有显著性 (P<0 .0 5 )。而毒副反应除一过性腹胀、腹痛外 ,无显著差异。结论 :腹腔 +全身序贯化疗对中晚期胃肠道癌有明显增效作用 ,且具有安全 ,低毒等优点。
OBJECTIVE: To observe the synergistic effect and toxicity of peritoneal and systemic sequential chemotherapy in patients with advanced gastrointestinal cancer. Methods: 5 - Fu + HCPT + DDP intraperitoneal perfusion combined with L V +5 - Fu + HCPT + DDP systemic chemotherapy and randomized comparable patients with similar systemic systemic chemotherapy (the latter) as a control, for more than 3 weeks assessment Efficacy and record side effects. Results: In the observation group, 2 cases were completely relieved (CR), 20 cases partially relieved (PR), and the total effective rate was 53.7%. In the control group, 38 cases were CR0 cases and PR11 cases, the total effective rate was 8.9% There was significant (P <0.05). Toxic side effects in addition to a transient bloating, abdominal pain, no significant difference. Conclusion: Intraperitoneal + systemic sequential chemotherapy has obvious synergistic effect on advanced gastrointestinal cancer, and has the advantages of safety, low toxicity and so on.