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胺碘酮是广泛应用的抗心律失常药物。在胺碘酮所致的各种副作用中,胺碘酮导致的肺毒性是最威胁生命的并发症,此种并发症一般出现在长期应用胺碘酮后有较高累积浓度的患者。胺碘酮短期应用导致的肺毒性报道较少,Lee等收治一例54岁男性患者,因心肌梗死后室性心动过速短期运用胺碘酮后导致肺毒性。患者因胸痛、ST段抬高心肌梗死入院。除吸烟外无其它易患因素及病史。冠状动脉造影示左前降支近端血栓致完全闭
Amiodarone is a widely used anti-arrhythmic drug. Among the various side effects caused by amiodarone, pulmonary toxicity due to amiodarone is the most life-threatening complication commonly seen in patients with higher cumulative concentrations after long-term use of amiodarone. Short-term application of amiodarone caused less pulmonary toxicity, Lee et al. A 54-year-old man was admitted to hospital for pulmonary toxicity after short-term amiodarone administration due to ventricular tachyarrhythmias after myocardial infarction. Patients with chest pain, ST elevation myocardial infarction admission. In addition to smoking and no other risk factors and medical history. Coronary angiography showed proximal thrombus caused by left anterior descending artery was completely closed