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Increasing attention is focused on the down-regulation of miRNAs in cancer process.Nuclear receptor subfamily 2 (NR2F2,also known as COUP-TFII) is involved in the development of many types of cancers,but its role in gastric cancer remains elusive.In this experiment,oncomine and Kaplan-meier database revealed that NR2F2 was up-regulated in gastric cancer and that the high NR2F2 expression contributed to poor survival.MicroRNA-27b was targeted and down-regulated by NR2F2 in human gastric cancer tissues and cells.The ectopic expression of miR-27b inhibited gastric cancer cell proliferation and tumor growth in vitro and in vivo.Assays suggested that the overexpression of miR-27b could promote MGC-803 cells’ migration and invasion and retard their metastasis to the liver.In addition,down-regulation of miR-27b enhanced GES-1 cells’ proliferation and metastasis in vitro.These findings reveal that miR-27b is a tumor suppressor in gastric cancer and a biomarker for improving patients’ survival.