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目的:观察泮托拉唑与托烷司琼+地塞米松联合治疗肿瘤患者化疗所致消化道不良反应的疗效和不良反应。方法:将80例化疗患者随机分为P、T两组,P组为治疗组,给予泮托拉唑+托烷司琼+地塞米松;T组为对照组,给于托烷司琼+地塞米松,比较两组的临床效果与药物不良反应。结果:治疗组在预防食欲不振、抑制恶心、呕吐等方面明显优于对照组(P<0.05);两组头晕、腹痛、便秘、乏力、颜面潮红、失眠等不良反应发生率相仿(P>0.05)。结论:泮托拉唑联合托烷司琼预防化疗所致消化道反应疗效好,值得临床推广。
OBJECTIVE: To observe the curative effect and adverse reactions of the combination of pantoprazole and tropisetron plus dexamethasone in the treatment of gastrointestinal adverse reactions caused by chemotherapy in cancer patients. Methods: Eighty patients with chemotherapy were randomly divided into P group and T group. P group was treated with pantoprazole + tropisetron + dexamethasone. T group was control group, Dexamethasone, the clinical effects and adverse drug reactions were compared between the two groups. Results: The treatment group was significantly better than the control group in preventing loss of appetite, inhibiting nausea and vomiting (P <0.05). The incidences of dizziness, abdominal pain, constipation, fatigue, flushing and insomnia in the two groups were similar (P> 0.05 ). Conclusion: Pantoprazole combined with tropisetron can prevent the digestive tract reaction induced by chemotherapy and is worthy of clinical promotion.