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目的 探讨不同肠化亚型与胃癌发生的关系。方法 采用ABC免疫组化的方法 ,观察不同亚型肠化中PHA和CEA的变化。结果 (1)不全结肠型肠化PHA阳性表达率89 .3 % (P <0 .0 1) ,显著高于其它三型肠化。 (2 )不全结肠型肠化CEA阳性检出率 85 .7% ,P <0 .0 5 ,亦显著高于其它三型。 (3 )癌旁肠化中不全结肠型肠化占 5 9% ,显著高于良性病变伴肠化 (2 1.7% ,P <0 .0 5 )。结论 不全结肠型肠化与胃癌的关系密切 ,尤其是伴PHA和CEA过表达的不全结肠型肠化 ,应视为真正的胃癌前病变。
Objective To investigate the relationship between different intestinal subtypes and gastric carcinogenesis. Methods ABC immunohistochemical method was used to observe the changes of PHA and CEA in different subtypes of intestinal metaplasia. Results (1) The positive expression rate of PHA in incomplete intestinal metaplasia was 89.3% (P <0.01), which was significantly higher than that in other three types of intestinal metaplasia. (2) The positive rate of CEA positive in incomplete intestinal metaplasia was 85.7%, P <0.05, which was also significantly higher than the other three types. (3) The adjacent intestinal metaplasia in parathyroid cancer accounted for 59%, which was significantly higher than that in benign lesions (27%, P <0.05). Conclusions Incomplete colon-type intestinal metaplasia is closely related to gastric cancer. In particular, incomplete intestinal-type intestinal metaplasia with over-expression of PHA and CEA should be regarded as a real precancerous lesions of the stomach.