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近年来,我们在用放射性核素研究云南白药的同时,以复方田七散进行对照,现将结果报告如下。一、对小鼠心肌营养血流量的影响在用同位素~(86)Rb研究云南白药时,将小鼠分为四组:(1)对照组:腹腔注射生理盐水;(2)已知增加心肌营养性血流量的药物对照组:异丙肾上腺素,皮下注射2.5mg/kg,潘生丁腹腔注射100mg/kg;(3)已知减少心肌营养性血流量的药物对照组:脑垂体后叶素,皮下注射0.15μ/kg;(4)云南白药及复方田七散:云南白药6g/kg,复方田七散一号6g/kg,均腹腔注人。以上各组分别在给药后不同时间(5分、15分、30分)将动物以颈椎脱臼法处死,切开心腔,取出心脏,作十字形切开,用常水洗去心室内和心脏表面的放射性,用滤纸吸干水后,放入0.5ml消化液中进行消化,并移去0.1ml作放射性测定,计数经统计学处理,结果可看出,云南白药在一定条件下可增加小鼠心肌营养性血流量,5分钟时增加
In recent years, we have used radionuclides to study Yunnanbaiyao and compared them with compound Tianqisan. The results are reported below. First, the impact of myocardial blood flow in mice in the use of isotope ~ (86) Rb study of Yunnanbaiyao, the mice were divided into four groups: (1) the control group: intraperitoneal injection of saline; (2) known to increase myocardial Nutritional blood flow drug control group: isoproterenol, subcutaneous 2.5 mg/kg, dipyridamole intraperitoneal injection of 100 mg/kg; (3) drug control group known to reduce myocardial nutrient blood flow: pituitrin, Subcutaneous injection of 0.15μ/kg; (4) Yunnanbaiyao and compound Tianqisan: Yunnanbaiyao 6g/kg, compound Tianqisan No. 1 6g/kg, were injected intraperitoneally. The animals in each group were sacrificed by cervical dislocation at different times (5 points, 15 minutes, and 30 minutes) after administration. The heart was cut, the heart was removed, and the heart was cut open. The heart chamber and the heart were washed with water. The radioactivity was filtered with filter paper to remove water and placed in 0.5 ml of digestive solution for digestion. 0.1 ml was removed for radioactivity determination. The counts were statistically processed. The results showed that Yunnan Baiyao can increase the mice under certain conditions. Myocardial nutritional blood flow, increased at 5 minutes