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作者检测了69例经羊膜腔穿刺证实为唐氏(Down)综合征妊娠和405例正常妊娠妇女(对照组)随意尿样本中游离β-人绒毛膜促性腺激素(β-hCG),β-核心片断和总雌三醇水平。尿样本收集在无菌容器中贮存在-20℃待用。对照组母亲年龄中位数是34.5岁(范围23～43岁);Down综合征组是36.0岁(范围21～44岁)。对照组孕龄中位数是18孕周(范围14～22孕周);Down综合征是19孕周(范围14～26孕周)。用CIS免疫放射测定游离β-hCG。所用的捕获抗体FBTTI与β-核心无交叉反应。所有尿样本按1:5
The authors tested for 69 cases of free β-hCG, β-hCG in random urine samples from 69 pregnant women with Down syndrome confirmed by amniocentesis and 405 normal pregnant women (control group) Core fragment and total estriol level. Urine samples were collected in sterile containers and stored at -20 ° C until use. The median age of mothers in the control group was 34.5 years (range 23-43 years) and in the Down Syndrome group was 36.0 years (range 21-44 years). The median gestational age in the control group was 18 gestation weeks (range, 14-22 weeks gestation); Down syndrome was 19 gestation weeks (range, 14-26 gestation weeks). Free beta-hCG was measured by immunostaining with CIS. The capture antibody used, FBTTI, did not cross-react with β-core. All urine samples by 1: 5