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目的:研究枸橼酸莫沙必利片治疗胃食管反流病的效果。方法:选择我院2011年3月~2012年3月51例胃食管反流患者作为观察组,患者在常规治疗的基础上加用枸橼酸莫沙必利片治疗,同时选择同期采用常规埃索美拉唑进行治疗的51例患者为对照组,采用视觉模拟评分法(VAS)在治疗前后进行评价,观察2组疼痛变化、治疗效果、不良反应及临床症状改变情况。结果:2组治疗后VAS评分均明显低于治疗前,观察组下降幅度较对照组明显,2组治疗后与治疗前比较差异具有统计学意义P<0.05。观察组与对照组比较比较差异具有统计学意义P<0.05。2组主要的不良反应是腹泻与皮疹,不良反应发生率分别为7.84%,5.88%;2组比较差异无显著性,无统计学意义P>0.05。观察组显效46例,有效5例,总有效率100%,对照组显效42例,有效3例,总有效率88.24%;2组比较差异具有显著性,有统计学意义P<0.05。结论:枸橼酸莫沙必利片可明显改善患者临床症状,胃食管反流病患者经治疗后效果显著,具有较高的安全性。
Objective: To study the effect of mosapride citrate tablets on gastroesophageal reflux disease. Methods: From March 2011 to March 2012, 51 cases of gastroesophageal reflux patients were selected as the observation group. Patients were treated with mosapride citrate tablets on the basis of routine treatment. At the same time, Fifty-one patients treated with SOM were used as control group. Visual analog scale (VAS) was used to evaluate the changes before and after treatment. The pain changes, treatment effects, adverse reactions and clinical symptoms were observed in two groups. Results: The VAS scores of two groups after treatment were significantly lower than those before treatment, and the decrease rate of the observation group was more obvious than that of the control group. The difference between the two groups after treatment was statistically significant (P <0.05). The difference between the observation group and the control group was statistically significant P <0.05.2 The main adverse reactions were diarrhea and rash, the incidence of adverse reactions were 7.84% and 5.88% respectively. There was no significant difference between the two groups Significance P> 0.05. The observation group was effective in 46 cases, effective in 5 cases, the total effective rate was 100%, 42 cases in the control group markedly effective in 3 cases, the total effective rate was 88.24%. There was significant difference between the two groups (P <0.05). Conclusion: Mosapride citrate tablets can significantly improve the clinical symptoms of patients with gastroesophageal reflux disease after treatment, the effect is significant, with high safety.