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目的探讨手足口病热程中的外周白细胞动态变化，摸索规律，为临床儿科医师提供诊疗理论依据。方法对2012年4月~8月住我院手足口病病房有发热的手足口病161例患儿，在入院时治疗前采集标本进行检测外周白细胞，包括白细胞(WBC)、中性粒细胞、淋巴细胞三项观察指标，以入院时热程长短分组，对各天检测结果进行统计学对比分析，观察动态变化规律。结果白细胞总数院1d结果为10.87±3.96(*109/L)，2d结果为11.18±5.13(*109/L)，3d结果为11.88±3.59(*109/L)，4d结果为9.87±3.59(*109/L)，5d结果为8.38±2.43(*109/L)，6d结果为9.99±4.2(*109/L)，7d结果为7.83±2.39(*109/L)。中性粒细胞总数：1d结果为5.18±2.52(*109/L)，2d结果为7.13±3.83(*109/L)，3d结果为7.35±4.23(*109/L)，4d结果为5.55±2.52(*109/L)，5d结果为2.49±1.73(*109/L)，6d结果为5.57±3.40((*109/L)，7d结果为2.51±1.24(*109/L)。在发热第2d，白细胞达到峰值，各天患儿外周白细胞各天之间的医学统计学变化差异有显著意义(<0.05)。结论手足口病患儿外周白细胞变化可能是一个动态变化过程，随时间变化而有不同结果。“,”Objective To investigate the thermal history of hand foot and mouth disease in peripheral leukocytes dynamic change,explore the law of diagnosis and treatment,to provide theoretical basis for clinical pediatrician.Methods 2012 April to 2012 August to live hand foot and mouth disease are fever ward in our hospital 161 cases of children with hand foot and mouth disease,in the before treatment were detected in peripheral white blood cel s,including white blood cel (WBC),neutrophils,lymphocytes of three observation indexes,observe the dynamic changes.Results The total number of white blood cel s:1D was 10.87±3.96(í109/L),2D was 11.18±5.13(í109/L),3D was 11.88±3.59(í109/L),4 D was 9.87±3.59(í109/L),5D was 8.38±2.43(í109/L),6D was 9.99±4.2(í109/L),7d was 7.83±2.39(í109/L).The total number of neutrophils:1D was 5.18±2.52(í109/L),2D was 7.13±3.83(í109/L),3D was 7.35±4.23(í109/L),4D was 5.55±2.52(í109/L),5D was 2.49±1.73(í109/L),6D was 5.57±3.40(í109/L) the results,7d was 2.51±1.24(í109/L).In second days of fever,white blood cel s reached the peak,a significant statistical dif erence between 7d changes in peripheral white blood cel ( <0.05).Conclusion HFMD patients with peripheral white blood cel changes may be a process of dynamic change,changes with time and have dif erent results.