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目的：探讨舍曲林联合齐拉西酮胶囊治疗难治性强迫症的临床疗效。方法：筛选2014年1月至2015年1月我院收治的难治性强迫症患者76例，作为研究对象。采用随机数表法将其分为观察组与对照组，每组患者38例，其中对照组患者单纯应用舍曲林治疗，观察组患者在舍曲林治疗的基础上加用齐拉西酮胶囊治疗，比较两组患者治疗后临床症状改善情况以及治疗总有效率。结果：两组患者治疗前Y-BOCS评分分比较无显著无显著差异，治疗6周后均有所改善，但观察组患者改善效果更为显著，与对照组比较存在显著差异(P<0.05)；观察组患者治疗总有效率为92.11%，明显高于对照组治疗总有效率78.95%，P0.05)。结论：采用舍曲林联合齐拉西酮胶囊治疗难治性强迫症疗效确切，较单纯用药具有更高的症状改善效果。“,”Objective To discuss the clinical effect of sertraline combined with ziprasidone capsule in the treatment of refractory obsessive-compulsive disorder.Methods 76 cases with refractory obsessive-compulsive disorder, which admitted in our hospital during January 2014 – January 2015, were selected as the research object and divided into the observation group and the control group each group of 38 cases, according to random number table method. The control group was given pure sertraline treatment and the observation group was given ziprasidone capsule treatment on the basis of sertraline treatment. Clinical symptoms improved after treatment and the total effective rate of the two groups were compared.Results Y - BOCS score before treatment in both groups was no significant difference. After treatment 6 weeks, there was some improvement of the two groups, while the improvement of the observation group was more significant, significant differences compared with control group (P<0.05). The total effective rate of the observation group was significantly higher than that of the control group 78.95%, the difference was significant statistically significant (P 0.05).Conclusion The sertraline combined with ziprasidone capsule in the treatment of refractory obsessive-compulsive disorder has exact curative effect, compared with the simple medication has higher symptom improvement effect, and the application security is higher, clinical application and popularization value.