论文部分内容阅读
目的肺脏是微波辐射的敏感靶部位之一,研究微波辐射后肺脏损伤效应,对于阐明微波辐射剂量效应、提供防治措施具有重要的意义。方法使166只二级雄性Wistar大鼠接受0、10、30和100 m W/cm~2微波辐射5 min,并于辐射后6 h、1 d、3 d,7 d和14 d处死各组大鼠,采用血气分析仪检测大鼠动脉血中Pa O2、Pa CO_2和p H值改变,通过计算肺湿/体比、干/体比和湿/干比变化,观察微波辐射后大鼠肺系数的改变。结果 10、30 m W/cm~2组微波辐射后各时间点Pa O2和PaCO_2未见明显改变,100 m W/cm~2组辐射后1 d,Pa O2下降(P<0.05),Pa CO_2升高(P<0.01),3 d后基本恢复。10、30 m W/cm~2组肺系数与假辐射组相比,于辐射后6 h时增加(P<0.05),1 d时恢复;100 m W/cm~2辐射后3 d内,肺系数均增加(P<0.05),7 d后基本恢复。结论 10~100 m W/cm~2微波辐射可导致大鼠肺通气和换气功能异常,肺系数增加;且此改变与辐射剂量具有相关性。
Objective Lung is one of the sensitive target sites for microwave radiation. Studying the effect of lung injury after microwave radiation is of great significance to elucidate the dose effect of microwave radiation and provide prevention and cure measures. Methods Sixty-two male Wistar rats were exposed to 0, 10, 30 and 100 mW / cm ~ 2 microwaves for 5 min and sacrificed at 6, 1, 3, 7 and 14 d after irradiation The PaO2, PaCO2 and p H values in arterial blood of rats were detected by blood gas analyzer. The changes of lung wet / body ratio, dry / body ratio and wet / dry ratio were observed. Change of coefficient. Results PaO2 and PaCO2 did not change significantly at all time points after 10 and 30 mW / cm ~ 2 microwave irradiation. PaO2 decreased (P <0.05) at 100 mW / cm ~ (P <0.01), and basically recovered after 3 days. Compared with the sham radiation group, the lung coefficient at 10,30 mW / cm ~ 2 increased at 6 h after radiation (P <0.05) and recovered at 1 d. Within 3 days after 100 mW / cm ~ 2 irradiation, Lung coefficient increased (P <0.05), after 7 d, basically recovered. Conclusion The microwave radiation of 10 ~ 100 mW / cm ~ 2 can lead to abnormal lung ventilation and ventilation in rats and increase of lung coefficient. And this change is related to radiation dose.