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用新选育的鼠疫菌苗０６１４Ｆ株在豚鼠基础免疫２０天后再加强免疫一次。结果表明，加强免疫２０天后血清Ｆ１抗体迅速达到高峰，几何平均滴度为１１４，至４个月时尚能１００％保护豚鼠耐受强毒鼠疫菌１４１株１０亿菌体的攻击，它比生物制品规程中免疫力试验要求攻击的菌量大１０５倍，仍然获得较好的免疫效果。作者认为，在鼠疫动物病流行猛烈的地区，鼠疫活菌苗施行两次接种，预计可提高易感人群的抗感染能力。
The newly-selected Y. pestis strain 0614F was boosted once more on the basis of guinea pig's basic immunity for 20 days. The results showed that after 20 days of intensive immunization, the serum F1 antibody peaked rapidly with a geometric mean titer of 114. By 4 months, the fashion was able to protect 100% of the guinea pigs from the challenge with 141 strains of virulent Yersinia pestis by 1 billion cells, Procedures immunity test requires 105 times the amount of bacteria attack, still get a better immune effect. The author believes that in the epidemic areas of plague animal disease epidemic, vaccination of live placenta vaccine twice, is expected to increase the susceptibility of susceptible populations.