【摘 要】
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Multishelled hollow structures have drawn increasing interest because of their peculiar compartmenta-tion environments and physicochemical properties. In this w
【机 构】
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Key Laboratory for Organic Electronics&Information Displays and Jiangsu Key Laboratory for Biosensor
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Multishelled hollow structures have drawn increasing interest because of their peculiar compartmenta-tion environments and physicochemical properties. In this work, deformable double-shelled hollow mesoporous organosilica nanocapsules (DDHMONs) were successfully synthesized by a multi-interfacial etching strategy. The obtained DDHMONs have a double-shelled structure with aninorganic-organic hybrid framework, a uniform outer layer (～320 nm) and inner layer (～180 nm), ordered mesochannels (～2.21 nm), and a large specific surface area (～1233 m2/g). In vitro toxicity tests show that the DDHMONs have excellent biocompatibility when coincubated with human breast cancer cells. In addition, the anticancer substance doxorubicin (DOX) can be highly loaded in DDHMONs (～335 μg/mg). The results from flow cytometry together with confocal laser scanning microscopy show that DOX can be efficiently delivered into MCF-7 cells by DDHMONs, thus improving chemotherapeutic efficiency and demonstrating that DDHMONs have potential nanomedicine applications as anticancer agents.
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