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目的通过血清胰岛素样生长因子(IGF)-1、前列腺特异抗原(PSA)和游离PSA(f-PSA)水平的定量检测,探讨其在前列腺疾病的临床诊断中的意义和价值。方法采用免疫放射分析法(IRMA)和免疫化学发光法检测18例前列腺癌(PCa)?30例良性前列腺增生(BPH)患者以及30例正常男性对照的血清IGF-1、f-PSA和PSA水平。结果与BPH组和正常男性对照组比较,PCa病人血清IGF-1(282.7±99.5vs153.5±48.5ng/ml,282.7±99.5vs138.7±47.5ng/ml,P均<0.01)、PSA(50.5±39.7vs7.2±3.7ng/ml,50.5±39.7vs1.6±1.0ng/ml,P均<0.01)和f-PSA(7.6±5.7vs1.8±1.0ng/ml,7.6±5.7vs0.6±0.3ng/ml,P均<0.01)水平均明显增高;BPH组血清PSA高于对照组(P<0.01),IGF-1和f-PSA与对照组比较差异无统计学意义(P均>0.05)。结论血清高水平的IGF-1与PCa发生密切相关,可作为一个新的PCa高危人群的预测指标,而将其与PSA、f-PSA等联合检测,对前列腺疾病的诊断和筛查更具重要意义。
Objective To investigate the significance and value of serum insulin-like growth factor (IGF) -1, prostate-specific antigen (PSA) and free PSA (f-PSA) in the clinical diagnosis of prostatic diseases. Methods The levels of IGF-1, f-PSA and PSA in 18 cases of prostate cancer (PCa), 30 cases of benign prostatic hyperplasia (BPH) and 30 cases of normal male controls were detected by immunoradiometric assay (IRMA) . Results Compared with BPH group and normal male control group, the serum levels of IGF-1 (282.7 ± 99.5vs153.5 ± 48.5ng / ml, 282.7 ± 99.5vs138.7 ± 47.5ng / ml, P <0.01) 50.5 ± 39.7 vs 7.2 ± 3.7 ng / ml, 50.5 ± 39.7 vs 1.6 ± 1.0 ng / ml, P <0.01) and f-PSA (7.6 ± 5.7 vs 1.8 ± 1.0 ng / .6 ± 0.3ng / ml, all P <0.01). The serum PSA in BPH group was higher than that in control group (P <0.01), and there was no significant difference between IGF-1 and f-PSA in control group All> 0.05). Conclusion Serum high level of IGF-1 is closely related to PCa, which may be used as a new predictor of PCa at high risk. Combined detection of serum IGF-1 and PSA is more important for the diagnosis and screening of prostate diseases significance.