ALLELIC FREQUENCIES OF PLASMA ALPHA-1-ANTITRYPSIN IN CHINESE

• 作 者: 应启龙 梁植权
• 机 构: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Acade
• 出 处: Science in China,Ser.B
• 发表日期: 1984年02期
• 关键词: populations mutant isoelectric Japanese ALPHA focusing allele neutral bands freq

Alpha-1-antitrypsin (Pi) types and subtypes in a Chinese population of 1049 unrelatedindividuals in Beijing were determined by separator isoelectric focusing. The low activityPi variant S and the deficient Pi variant Z, common in most Caucasian populations, are ab-sent in the Chinese population. The frequent Pi variant found in the Chinese population isa neutral mutant, Etokyo, which was only found in Japanese before. Thus, it is concludedthat, as a predisposition of obstructive or some other lung diseases and liver diseases, thegenetic determined deficiency of alpha-1-antitrypsin in Chinese is not so important as in mostCaucasian populations.

Alpha-1-antitrypsin (Pi) types and subtypes in a Chinese population of 1049 unrelatedindividuals in Beijing were determined by iso-isoelectric focusing. The low activityPi variant S and the deficient Pi variant Z, common in most Caucasian populations, are ab-sent in the Chinese population. The frequent Pi variant found in the Chinese population isa neutral mutant, Etokyo, which was only found in Japanese before. Thus, it is concluded that as a predisposition of obstructive or some other lung diseases and liver diseases, the genetic determination deficiency of alpha-1-antitrypsin in Chinese is not so important as in mostCaucasian populations.