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目的 探讨败血症与医院感染发展的趋势 ,致病菌的变迁。方法 回顾性分析 1995年 3月～ 1999年 3月间 ,经血培养和临床资料证实的 10 4例 10 9次败血症。结果 10 4例 10 9次败血症中院内感染占 5 2 .9% ,院外感染占 47.1% ;本组败血症有严重基础病与易感因素占 88.5 % ;致病菌分布特点有 :G- 菌呈上升趋势 ,G- 菌则有下降趋势 ,但仍以 G-菌为主 ;条件致病菌、复数菌和真菌感染发生率明显增加 ;本组院内感染病死率高(34 .5 6 % ) ,这往往与宿主防御机能或诱因因素有关。结论 G+菌败血症呈上升趋势 ,G-菌则有下降趋势 ,条件致病菌和真菌败血症发生率明显增多 ;应注意合理用药、细菌培养和药敏试验。
Objective To explore the trend of development of sepsis and nosocomial infection and the change of pathogenic bacteria. Methods A retrospective analysis of 10 4 sepsis cases confirmed by blood culture and clinical data from March 1995 to March 1999 was performed. Results 10 4 cases of sepsis 109 cases accounted for 52.9% of nosocomial infections, nosocomial infections accounted for 47.1%; sepsis in this group has a serious underlying disease and susceptibility factors accounted for 88.5%; distribution of pathogenic bacteria are: G- However, G- bacteria still dominated. The incidences of opportunistic bacteria, complex bacteria and fungal infections were significantly increased. The mortality rate of nosocomial infections in this group was high (34.56%), This is often related to the host defense function or incentive factors. Conclusions G + septicemia is on the rise, while G- bacteria is on a downward trend. The incidences of opportunistic pathogens and fungal sepsis are obviously increased. Reasonable drug use, bacterial culture and drug sensitivity test should be paid attention to.