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含有氧化还原酶的WW结构域(WW domain containing oxidoreductase,WWOX)基因是由Bednarek等[1]在染色体脆性位点FRA16D(16q23.3-24.1)区域克隆出的一个新的基因。近年研究发现WWOX基因与多种恶性肿瘤的发生、发展密切相关,被认为是一个新的候选抑癌基因。本文就WWOX基因与恶性肿瘤的研究进展作一综述。1 WWOX基因及其结构
WW domain containing oxidoreductase (WWOX) gene is a new gene cloned by Bednarek et al [1] in the FRA16D (16q23.3-24.1) region of the chromosomal fragile locus. Recent studies found that WWOX gene is closely related to the occurrence and development of many malignant tumors and is considered as a new candidate tumor suppressor gene. This article reviews the research progress of WWOX gene and malignant tumor. 1 WWOX gene and its structure