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193名接种血源乙肝疫苗后6年的中学生分别加强接种乙肝基因疫苗和血源疫苗后一个月抗-HBs阳转率（91．21％、90．20％）均显著高于加强接种前（79．21％、68．68％、P＜0．05、P＜0．01），加强接种前后两种疫苗组抗-HBs阳转率间差别无显著性意义。加强接种前抗-HBs＜10IU／L或≥10IU／L者加强接种不同疫苗后，抗-HBsGMT均无显著性差别，加强接种前抗-HBs滴度越高，加强后抗-HBs滴度上升率越低（P＜0.01）。初免后无或弱免疫应答者分别再种不同疫苗后，均有部分获得有效免疫，多因素分析结果，加强前是否感染乙肝病毒和抗-HBs水平对加强后抗-HBs水平有一定影响。
The anti-HBs positive rate (91.21%, 90.20%) of 193 HBsAg-seroprevalence vaccines and blood-borne vaccines were significantly higher than that of the control group 79.21%, 68.68%, P <0.05, P <0.01). There was no significant difference between the two vaccines groups before and after vaccination in anti-HBs positive rate. There was no significant difference in anti-HBsGMT after vaccination with different vaccines before anti-HBs <10IU / L or ≥10IU / L before vaccination. The titer of anti-HBs was increased before vaccination, and the titer of anti-HBs was increased The lower the rate (P <0.01). After vaccination, patients with or without immune response were immunized with different vaccines, respectively, and some of them were effectively immunized. Multivariate analysis showed that the level of HBV and anti-HBs was not significantly enhanced before HBsAg and anti-HBs were increased.