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目的探究顽固性呃逆与菌群失调及真菌二重感染的相关性。方法对使用抗生素后发生顽固性呃逆的患者120例,首先均进行常规治疗,同时进行实验室真菌检查,根据真菌检查阳性与否分为A、B两组,其中真菌检查阳性组(A组)52例和真菌检查阴性组(B组)68例。对A组52例进行抗真菌药物治疗,根据抗生素是否继续使用再分A1、A2两组,其中继续抗生素加抗真菌药物治疗组(A1组)32例和停抗生素加抗真菌药物治疗组(A2组)20例;对B组68例再随机分为B1、B2两组,包括停抗生素加常规治疗组(B1组)34例和继续抗生素加抗真菌药物治疗组(B2组)34例。观察各组顽固性呃逆的疗效,以及各组之间的疗效对比,顽固性呃逆与抗生素、菌群失调及真菌二重感染的关系。结果常规治疗均效果不好,抗生素只能使顽固性呃逆病情加重,抗真菌药物治疗起效快,效果好,治愈率高达95%左右,有效率达100%。结论顽固性呃逆与使用抗生素引起的菌群失调及真菌二重感染有相关性,抗真菌药物治疗对终止顽固性呃逆疗效显著。
Objective To investigate the correlation between intractable hiccups and bacterial flora and fungal double infection. Methods A total of 120 patients with intractable hiccup after antibiotics were treated with routine treatment and laboratory fungal tests. According to the fungal positive tests, the patients were divided into A and B groups, of which fungal positive group (A group) 52 cases and fungal negative group (B group) 68 cases. A group of 52 cases of antifungal therapy, according to whether the continued use of antibiotics A1, A2 two groups, including antibiotics plus antifungal drug treatment group (A1 group) 32 patients stopped antibiotics plus antifungal drug treatment group (A2 (N = 20). Sixty-eight patients in group B were randomly divided into two groups (B1 and B2), including 34 patients receiving antibiotics plus conventional treatment (group B1) and 34 patients continuing antibiotics plus antifungal drug treatment (group B2). To observe the curative effect of intractable hiccup in each group, and compare the curative effect of each group, the relationship between intractable hiccup and antibiotics, flora imbalance and fungal double infection. Results The results of routine treatment were ineffective, antibiotics can only make refractory hiccups aggravate, antifungal therapy rapid onset, the effect is good, the cure rate as high as 95%, the effective rate of 100%. Conclusions The intractable hiccups are related to the flora imbalance caused by antibiotics and the double infection of fungi. Antifungal therapy is effective in stopping the intractable hiccup.