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为探讨十二指肠溃疡（ＤＵ）患者血清试餐胃泌素（ＭＳＧ）对幽门螺杆菌（ＨＰ）感染的反应，评估抗ＨＰ治疗后ＭＳＧ的降低水平及其用于判定ＨＰ根除效果的可靠性，对５２例ＨＰ阳性ＤＵ患者治疗前后分别进行胃镜检查，取胃粘膜ＨＰ培养、病检及快速尿素酶试验，并测定其血清ＭＳＧ浓度。结果发现，ＤＵ患者血清ＭＳＧ浓度（１５４８±６３８ｐｇ／ｍｌ）较对照组（６０９±２５８ｐｇ／ｍｌ）明显升高（Ｐ＜０００１），但经治疗后，ＨＰ被根除者ＭＳＧ明显下降（５６５±１７７ｐｇ／ｍｌ），与治疗前比较差异有非常显著性（Ｐ＜０００１）。ＨＰ未根除者ＭＳＧ下降不明显（１２８２±２３５ｐｇ／ｍｌ），与治疗前比较差异无显著性（Ｐ＞００５）。如果以ＭＳＧ下降率≥３０％视为ＨＰ根除，与ＨＰ培养、病检及尿素酶方法比较，其敏感性为８７０％，特异性为８３３％，阳性预测值９７５％，阴性预测值４５５％，准确性８６５％。提示ＨＰ感染可引起ＤＵ患者血清ＭＳＧ升高，ＨＰ根除后则迅速下降，其一定范围的降低幅度可能对判定ＨＰ根除是一可靠的，无创伤性的较好指标
To assess the response of serum gastrin (MSG) to Helicobacter pylori (HP) infection in patients with duodenal ulcer (DU) and to assess the level of MSG reduction after anti-HP treatment and to determine the reliability of HP eradication The 52 cases of HP-positive DU patients before and after treatment were gastroscopy, the culture of gastric mucosa HP, pathological examination and rapid urease test, and determination of serum MSG concentration. The results showed that the serum MSG concentration of DU patients was significantly higher than that of the control group (1548 ± 638pg / ml) (609 ± 258pg / ml) (P <0001) The eradication MSG was significantly decreased (565 ± 177pg / ml), compared with the pre-treatment difference was significant (P <0001). There was no significant difference (P> 0.05) between the non-eradication group and the non-eradication MSG group (128.2 ± 23.5 pg / ml). If the MSG descending rate of ≥ 30% as HP eradication, compared with HP culture, pathological examination and urease method, the sensitivity was 87 0%, the specificity was 83 3%, the positive predictive value was 97 5% The negative predictive value was 455% and the accuracy was 865%. Tip HP infection can cause elevated serum MSG in patients with DU, HP eradication is rapidly decreased, and its extent may be reduced to determine the extent of HP eradication is a reliable, non-invasive better indicators