论文部分内容阅读
观察了小鼠接种高分泌ＩＬ－４的黑色素瘤细胞后腹腔内巨噬细胞功能的变化。荷瘤小鼠腹腔内巨噬细胞杀伤性在荷瘤后第４天及第１２天出现两个高峰；荷瘤后第１５天小鼠腹腔内巨噬细胞的吞噬能力及ＭＨＣⅡ类抗原的表达增强，抗原提呈能力增高；荷瘤后第４天及第１２天腹腔内巨噬细胞经诱导的ＩＬ－１水平出现两个高峰，经诱导的ＴＮＦ水平变化不明显。此实验结果表明，高分泌ＩＬ－４的黑色素瘤细胞体内生长受抑制的原因之一是ＩＬ－４基因的导入及ＩＬ－４的分泌使体内巨噬细胞的抗原提呈能力增强及杀伤活性的显著提高，因而使机体抗肿瘤免疫功能得以增强。
The changes of intraperitoneal macrophage function after mice were inoculated with IL-4 secreting melanoma cells were observed. Intraperitoneal macrophage cytotoxicity in tumor-bearing mice showed two peaks on the 4th and 12th day after tumorigenesis. Phagocytosis of macrophages and expression of MHC class II antigen in mice peritoneal cavity on the 15th day after tumorigenesis were enhanced , And the antigen presenting ability was increased. Two peaks appeared on the level of IL-1 induced by intraperitoneal macrophages on the 4th and 12th day after tumor-bearing, and the induced TNF level did not change obviously. This experimental result shows that one of the reasons why the growth of melanoma cells secreting high IL-4 is inhibited is that the introduction of IL-4 gene and the secretion of IL-4 enhance the antigen-presenting ability of macrophages in vivo and the killing activity Significantly increased, thus enabling the body to enhance anti-tumor immune function.