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目的 :探讨加速超分割放射治疗食管癌的疗效及放射反应和并发症。 方法 :80例胸段食管癌患者随机分为常规分割放疗组 (常规组 )和加速超分割放疗组 (加速超分割组 )。常规组 40例 ,每天照射 1次 ,每次 2 Gy,每周 5次 ,总剂量 70 Gy。加速超分割组 40例 ,其前 2 / 3疗程放射方法同常规组 ,剂量 40 Gy,后 1/ 3疗程每天照射 2次 ,每次 1.5 Gy,2次间隔时间 6 h以上 ,总剂量 70 Gy。所有患者采用 10 m V X线照射。 结果 :加速超分割组的 3年实际生存率和原发肿瘤控制率明显高于常规组 ,分别为 42 .5 %比 2 0 .0 %和 5 2 .5 %比 2 5 .0 %。两组的放射反应和并发症无显著差异 ,所有患者按计划完成了治疗。 结论 :加速超分割放疗食管癌较常规分割放疗明显提高了局控率和生存率 ,放射反应和并发症无明显增加 ,患者能够耐受该治疗方法
Objective: To investigate the therapeutic effect and radiation response and complications of accelerated hyperfraction radiotherapy for esophageal cancer. Methods: Eighty patients with thoracic esophageal cancer were randomly divided into routine radiotherapy group (conventional group) and accelerated hyperfraction radiotherapy group (accelerated hyperfractionation group). The conventional group of 40 cases, 1 day irradiation, each 2 Gy, 5 times a week, the total dose of 70 Gy. Forty patients underwent accelerated hyperfractionation. The first two-thirds of the radiotherapy methods were the same as those of the conventional one. The dose was 40 Gy. The last one-third of the radiotherapy was performed twice daily with 1.5 Gy each. The interval time was more than 6 h. The total dose of 70 Gy . All patients received 10 mV X-ray. Results: The 3-year actual survival rate and primary tumor control rate in accelerated hyperfractionation group were significantly higher than those in the conventional group (42.5% vs. 20.0% vs 52.5% vs. 25.0%, respectively). Radiation response and complications in both groups no significant difference, all patients completed the planned treatment. Conclusion: Accelerated hyperfraction radiotherapy esophageal cancer than conventional radiotherapy significantly increased the rate of control and survival rate, radiation response and complications no significant increase in patients with tolerance to the treatment