【摘 要】
：
目的 姜黄作为药食同源物质之一在我国被广泛使用,基于安全性的考虑,有必要对姜黄进行健康危害评估.方法 本文基于系统文献检索(Systematic Literature Searches,SLS)方法,收集姜黄的有效毒理学数据,开展其危害评估.结果 姜黄素在动物及人体内吸收入血快,主要分布在肾、肝和肠道中,粪便为主要排泄途径.姜黄急性毒性属实际无毒,小鼠经口LD50＞100g/kg.bw.亚急性、亚慢性毒性试验显示姜黄会引起实验动物肝、肾和脾局灶性坏死.慢性毒性动物实验显示,长期使用姜黄会引起胃肠道非肿瘤性
【机 构】
：
北京市疾病预防控制中心/北京市预防医学研究中心,食物中毒诊断溯源技术北京市重点实验室,北京100013;北京市大兴区疾病预防控制中心,北京102600;北京市疾病预防控制中心/北京市预防医学研究中心,
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目的 姜黄作为药食同源物质之一在我国被广泛使用,基于安全性的考虑,有必要对姜黄进行健康危害评估.方法 本文基于系统文献检索(Systematic Literature Searches,SLS)方法,收集姜黄的有效毒理学数据,开展其危害评估.结果 姜黄素在动物及人体内吸收入血快,主要分布在肾、肝和肠道中,粪便为主要排泄途径.姜黄急性毒性属实际无毒,小鼠经口LD50＞100g/kg.bw.亚急性、亚慢性毒性试验显示姜黄会引起实验动物肝、肾和脾局灶性坏死.慢性毒性动物实验显示,长期使用姜黄会引起胃肠道非肿瘤性病变.另外,姜黄油树脂饮食会引起实验动物肠系膜淋巴结窦扩张和甲状腺滤泡上皮细胞增生的发生率增加.结论 在现有的研究中,Ames实验研究显示姜黄的主要成分姜黄素无致突变性,但是在一定条件下有致癌性和致染色体断裂可能性.有动物实验证明长期食用姜黄素对生殖系统会产生一定损伤,但停止用药后恢复正常.人群资料表明,外用姜黄时可能会产生过敏反应.
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