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目的 :为比较聚众和散在静脉吸毒人员人类免疫缺陷病毒 (HIV)、乙型肝炎病毒 (HBV)、丙型肝炎病毒 (HCV)感染和重叠感染的差异。方法 :用ELISA法对 79份浙江境内静脉吸毒者 (15份为聚众静脉吸毒者 ,6 4份为散在静脉吸毒者 )血清进行HIV、HBV、HCV血清标志物检测。结果 :15份聚众静脉吸毒者血清抗HIV10 0 % (15 15 )阳性 ,抗HCV93 3% (14 15 )阳性 ,86 7% (13 15 )HBV感染标志物阳性 ;6 4份散在静脉吸毒者血清抗HIV无 1例阳性 ,抗HCV2 1 9% (14 6 4)阳性 ,82 8% (5 4 6 4)HBV感染标志物阳性。聚吸组抗HIV、抗HCV阳性显著高于散吸组 (P <0 0 0 1) ,而HBV感染标志物阳性两组间无显著性差异 (P >0 0 5 ) ;聚吸组HIV重叠HBV感染为 86 3%(13 15 ) ,HIV重叠HCV感染为 93 3% (14 15 ) ,HBV重叠HCV感染为 80 0 % (12 15 ) ,HIV、HBV、HCV三重感染为 6 6 7% (10 15 ) ,与散吸组存在显著性差异 (P <0 0 0 1)。结论 :聚众静脉吸毒者比散在静脉吸毒者有更高的HIV、HCV感染 ;聚众静脉吸毒者比散在静脉吸毒者有更高的HIV、HBV、HCV重叠感染
PURPOSE: To compare the differences in human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) infection and overlapping infection among polygamous and dispersed intravenous drug users. Methods: The serological markers of HIV, HBV and HCV in 79 samples of intravenous drug addicts in Zhejiang province (15 polygamous drug addicts and 64 in scattered intravenous drug addicts) were detected by ELISA. Results: Serum samples from 15 polygalactool users were positive for anti-HIV10 (15 15), positive for anti-HCV93 3% (14 15) and positive for 86 7% (13 15) HBV markers. Six out of 4 intravenous drug users None of the cases were positive for anti-HIV, positive for anti-HCV 21 9% (14 6 4), and positive for 82 8% (5 464) HBV infection. The positive rates of anti-HIV and anti-HCV in poly-sucking group were significantly higher than those in diffuse sucking group (P <0.01), but there was no significant difference between the two groups (P> 0.05) The prevalence of HBV infection was 86.3% (13.15), 93.3% (14/15) for HIV overlap, 80.0% (12.5%) for HBV overlap, and 66.7% for HIV, HBV and HCV 10 15), there was a significant difference with the diffusive group (P <0.01). CONCLUSIONS: Polygalacturonal drug users have higher HIV and HCV infection than intravenous drug users, and people with polyphagous intravenous drug abusers have higher HIV, HBV and HCV infection rates than intravenous drug users