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目的评价大剂量５－ＦＵ（４０００ｍｇ／ｍ２）持续９６小时静脉输注联合方案对晚期头颈部鳞癌的疗效和不良反应。方法采用上述５－ＦＵ联合方案治疗晚期头颈部鳞癌５５例，其中联合ＤＤＰ＋ＰＹＭ（ＰＰＦ方案）３５例，联合ＤＤＰ（ＰＦ方案）２０例。结果完全缓解（ＣＲ）１１例，部分缓解（ＰＲ）２４例，稳定（Ｓ）１１例，进展（Ｐ）９例，有效率（ＣＲ＋ＰＲ）６３．６％。全组中位生存期１３．１月。不良反应主要为恶心、呕吐（８５．５％），白细胞降低（３６．４％），血小板降低（９．１％），口腔粘膜溃疡及腹泻（６０．０％），外周静脉炎（６９．１％）等。结论本方案对头颈部鳞癌有较好疗效，骨髓抑制轻，但消化道粘膜毒性和外周静脉炎较重
Objective To evaluate the efficacy and adverse reactions of high-dose 5-FU (4000mg/m2) continuous intravenous infusion for 96 hours for advanced head and neck squamous cell carcinoma. Methods The above-mentioned 5-FU combination regimen was used to treat 55 cases of advanced head and neck squamous cell carcinoma, including 35 cases of combined DDP+PYM (PPF regimen) and 20 cases of combined DDP (PF regimen). Results There were 11 cases of complete remission (CR), 24 cases of partial remission (PR), 11 cases of stable (S), 9 cases of progression (P), and 63.6% of effective rate (CR+PR). The median survival time of the whole group was 13.1 months. Adverse reactions were mainly nausea and vomiting (85.5%), white blood cells (36.4%), platelet decrease (9.1%), oral mucosal ulcers and diarrhea (60.0%), and peripheral phlebitis (69. 1%) etc. Conclusion This protocol has good curative effect on squamous cell carcinoma of the head and neck with mild myelosuppression, but severe gastrointestinal mucosal toxicity and peripheral phlebitis