论文部分内容阅读
Background:The prevalence ofthrombocytopenia among Chinese antiretroviral therapy (ART)-na(i)ve HIV-infected adults has not been well-described.The aim of this study was to investigate the prevalence and associated risk factors of thrombocytopenia among Chinese ART-na(i)ve HIV-infected adults.Methods:We performed a cross-sectional study of Chinese adult ART-na(i)ve HIV-infected patients from September 2005 through August 2014.Socio-demographic variables and laboratory results including platelets,CD4+ cell count,and viral load were obtained from medical records.Factors and outcomes associated with thrombocytopenia were assessed using logistic regression.Results:A total of 1730 adult ART-na(i)ve HIV-infected patients was included.The mean age was 38 years.The prevalence of thrombocytopenia was 4.5％.There were significant differences in the prevalence of thrombocytopenia between patients ＜30 years of age (2.8％) and 30-39 years (4.0％) compared with patients greater than 50 years (7.0％) (P =0.006 and P =0.044,respectively).The prevalence of thrombocytopenia was also significantly different between patients with CD4+ counts of 200-349 cells/mm3 (3.3％) and ＞350 cells/mm3 (2.8％) compared with patients with CD4+ counts of50-199 cells/mm3 (7.1％) (P =0.002 and P =0.005,respectively).The prevalence of thrombocytopenia was significantly different by hepatitis C virus antibody (HCV-Ab) seropositivity (10.2％ for HCV-Ab positive vs.3.9％ for HCV-Ab negative,P =0.001).We observed differences in prevalence of thrombocytopenia by mode of transmission of HIV infection:Blood transmission (10.7％) versus men who have sex with men (3.9％) (P =0.002) and versus heterosexual transmission (3.9％) (P =0.001).In binary logistic regression analyses,age ≥＞50 years,HCV-Ab positivity and having a CD4+ cell count of 50-199 cells/mm3 were significantly associated with thrombocytopenia with adjusted odds ratio of 2.482 (95％ confidence interval [CI]:1.167,5.281,P=0.018),2.091 (95％ CI:1.078,4.055,P =0.029) and 2.259 (95％ CI:1.028,4.962,P =0.042),respectively.Conclusions:Thrombocytopenia is not common among adult ART-na(i)ve HIV-infected patients in China.Older age (age over 50 years),HCV-Ab positivity and lower CD4+ cell count are associated with an increased risk of thrombocytopenia.Therefore,early diagnosis and treatment of thrombocytopenia in these patients are necessary.