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目的:分析石河子人民医院药品不良反应(ADR)发生的相关因素,为临床合理用药提供参考依据。方法:收集2012-2013年我院上报的452例ADR报告,分别从ADR的级别、患者性别、年龄、给药途径、引发ADR的药品种类、ADR累及器官和(或)系统及临床表现、ADR转归的评价等方面进行统计、分析。结果:452例ADR报告中,新的/严重的ADR为136例(占30.09%);发生ADR患者男女性别比例无明显差异;10岁以下患者ADR发生率高于其他年龄段(242例,占53.54%);静脉给药引发的ADR为285例(占56.21%);引发ADR最常见的是化学药(354例,占75.48%);ADR的临床表现以消化系统损害为主(122例,占25.85%),其次为血液系统损害(120例,25.42%)。结论:新的/严重的ADR报告在分析和评价中意义重大,加强和重视药品不良反应报告和监测工作,提高临床安全用药水平,控制药物不良反应,确保用药安全。
Objective: To analyze the related factors of adverse drug reaction (ADR) in Shihezi People’s Hospital and provide a reference for clinical rational drug use. Methods: A total of 452 ADR cases reported in our hospital from 2012 to 2013 were collected from ADR level, patient’s sex, age, route of administration, the type of drug causing ADR, organ involvement and / or system and clinical manifestations of ADR, ADR The outcome of the evaluation and other aspects of statistics, analysis. Results: There were 136 cases (30.09%) of the new / severe ADRs in 452 ADR cases. There was no significant difference in the sex ratio of ADR patients among the ADR cases. The incidence of ADR in the ADR cases was higher than other age groups (242 cases, accounting for 53.54%). The ADR caused by intravenous administration was 285 cases (56.21%). The most common chemical drug was ADR (354 cases, accounting for 75.48%). The clinical manifestations of ADR were mainly digestive system damage (122 cases, Accounting for 25.85%), followed by blood system damage (120 cases, 25.42%). Conclusion: The new / serious ADR report is of great significance in the analysis and evaluation. The reports and monitoring of adverse drug reactions should be strengthened and monitored. The clinical safety dosage should be increased, adverse drug reactions should be controlled and drug safety ensured.