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目的:探讨在子宫体积超过孕14周的子宫肌瘤患者术前使用促性腺激素释放激素激动剂(Gn RHa)的治疗效果及其对腹腔镜手术的影响。方法:选取本院2012年5月至2014年5月收治的26例子宫肌瘤患者,术前给予醋酸亮丙瑞林微球3.75 mg,进行治疗,在患者停药后1~2个月行肌瘤剔除数或腹腔镜全子宫切除术,记录醋酸丙瑞林治疗前后患者的血红蛋白水平变化,肌瘤体积和术中出血量等情况。结果:治疗后的子宫肌瘤体积显著缩小,与治疗前比较,差异具有统计学意义(P<0.05)。治疗后的血红蛋白水平显著升高,与治疗前比较,差异具有统计学意义(P<0.05)。结论:在超过孕14周子宫体积的子宫肌瘤患者术前2个月采用Gn RH治疗,肌瘤体积显著缩小,血红蛋白水平明显提高,并使患者顺利的完成腹腔镜手术治疗。
Objective: To investigate the effect of gonadotropin-releasing hormone agonist (Gn RHa) preoperatively on patients with uterine fibroids over 14 weeks pregnant and their effect on laparoscopic surgery. Methods: Twenty-six patients with uterine fibroids admitted from May 2012 to May 2014 in our hospital were treated with 3.75 mg leuprolide microspheres preoperatively for treatment. The patients were treated 1 to 2 months after drug withdrawal Myomectomy or laparoscopic hysterectomy, recording the change of hemoglobin level, fibroids volume and intraoperative blood loss of patients before and after treatment with Clarithromycin. Results: After treatment, the volume of uterine fibroids significantly reduced, compared with before treatment, the difference was statistically significant (P <0.05). After treatment, hemoglobin levels were significantly increased, compared with before treatment, the difference was statistically significant (P <0.05). CONCLUSIONS: Gn RH was used in patients with uterine leiomyoma that exceeded 14 weeks of uterine volume pregnancy. The volume of fibroids was significantly reduced, hemoglobin level was significantly increased, and patients were successfully treated with laparoscopic surgery.