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Objective:To document Toxoplasma gondii(T.gondii) antibody status in patients with liver disease,blood samples were taken from 180 hepatic patients and 180 healthy controls.Methods:Toxoplasma IgG antibody was detected using enzyme-linked immunosorbent assay and histopathological assessment of liver biopsy METAVIR score was applied.Results:Anti-T.gondii IgG antibodies were found in 32.8%of patients and in 22.2%of controls(P=0.02).Toxoplasma seropositivity was significantly associated with lymphadenopathy,history of blood transfusion and reflex impairment in patients.Chronic hepatitis C virus(HCV)and chronic HCV-related cirrhosis groups compared to chronic HBV and chronic HBV-related cirrhosis groups expressed significantly higher prevalence of T.gondii seropositivity(odds ratio(OR) =4;95%confidence interval(CI):1.3-12.6;P=0.013,OR=4.8;95%CI:1.5-14.9;P=0.006,respectively).Within the chronic HCV group,T.gondii seropositivity significantly associated disease evolution as regards to METAVIR histopathological system for fibrosis and inflammation(OR=19.4;95%CI:2.3-165.2;P=0.0008,OR=0.29;95%CI:0.1-0.8;P=0.01,respectively).Albumin,international normalized ratio(INR) and platelets count were the laboratory parameters significantly altered in Toxoplasma-positrvc chronic HCV patients(P=0.00 l,0.03,0.04,respectively).Child-Pugh scoring for cirrhosis in chronic HCV group placed the majority of seropositive patient in class C with significant statistical difference compared to Child A reference group(OR= 0.08;95%67:0.01-0.5;P=0.003).Conclusions:Toxoplasma seropositivity was high in patients with cirrhosis and associated higher grades of inflammation and necrosis signifying disease evolution,suggesting that cirrhotic patients may thus form a risk group for toxoplasmosis.
Objective: To document Toxoplasma gondii (T.gondii) antibody status in patients with liver disease, blood samples were taken from 180 hepatic patients and 180 healthy controls. Methods: Toxoplasma IgG antibody was detected using enzyme-linked immunosorbent assay and histopathological assessment of liver biopsy METAVIR score was applied. Results: Anti-T.gondii IgG antibodies were found in 32.8% of patients and in 22.2% of controls (P = 0.02) .Toxoplasma seropositivity was significantly associated with lymphadenopathy, history of blood transfusion and reflexibility in patients. Chronic hepatitis C virus (HCV) and chronic HCV-related cirrhosis groups compared to chronic HBV and chronic HBV-related cirrhosis groups showed significantly higher prevalence of T.gondii seropositivity (odds ratio (OR) = 4; 95% confidence interval ( CI): 1.3-12.6; P = 0.013, OR = 4.8; 95% CI: 1.5-14.9; P = 0.006, respectively) .Within the chronic HCV group, T.gondii seropositivity significantly associated disease evolution as regards to METAVIR The histopathological system for fibrosis and inflammation (OR = 19.4; 95% CI: 2.3-165.2; P = 0.0008, OR = 0.29; 95% CI: 0.1-0.8; and platelets count were the laboratory parameters significantly altered in Toxoplasma-positrvc chronic HCV patients (P = 0.00 l, 0.03,0.04, respectively) .Child-Pugh scoring for cirrhosis in chronic HCV group placed the majority of seropositive patients in class C with significant Statistical difference compared to Child A reference group (OR = 0.08; 95% 67: 0.01-0.5; P = 0.003) .Conclusions: Toxoplasma seropositivity was high in patients with cirrhosis and associated higher grades of inflammation and necrosis signifying disease evolution, suggesting that cirrhotic patients may thus form a risk group for toxoplasmosis.