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“口腔干燥症”(xerostomia)可由各种临床方法诊断,如口腔粘膜望诊、唾液量测定、唾液腺活组织检查及腮腺RI 扫描检查等。然而,目前尚无一种有效的生物化学诊断法。脱氧核糖核酸酶(DNase)已知是细胞溶酶体之一,并分布在人体各种组织中。作者曾研究证明人唾液中酸性DNA 酶作用随年龄增长而减少,唾液分泌量随年龄增长而减少。因此唾液中酸性DNA 酶活性可看作能反映唾液腺的细胞功能的指标。必须确定是否有其它类型的DNA 酶(如中性DNA酶)也能反映这些细胞功能。本文检查了人腮腺中的酸性和中性DNA 酶活性,并对英与唾液功能的关系进行讨论。材料和方法:选择32名健康人,20～83岁,17名男性,15名女性。所有唾液通过自发流涎收集,测定无刺激条件下10分钟的分泌率。腮腺通过酸糖果刺激,用杯状套管收
“Xerostomia” can be diagnosed by various clinical methods, such as oral mucosal look-up, saliva measurement, salivary gland biopsy and Parotid RI scan. However, there is currently no effective biochemical diagnostic method. DNase is known as one of the cell lysosomes and is distributed in various tissues of the human body. The authors have studied to prove that the role of acid DNase in human saliva decreased with age, salivary secretion decreased with age. Therefore, salivary acid DNase activity can be seen as an indicator of cellular function of salivary glands. It must be determined whether other types of DNase (such as neutral DNase) also reflect these cell functions. This article examines the human parotid gland acidic and neutral DNase activity, and the relationship between British and saliva function are discussed. Materials and Methods: 32 healthy people, 20 ~ 83 years old, 17 males and 15 females were selected. All saliva were collected by spontaneous salivation and the rate of secretion for 10 minutes was measured in the absence of irritation. Parotid stimulated by acid candies, with a cup-shaped casing closed