论文部分内容阅读
目的探讨煤工尘肺进行性大块纤维化(progressive massive fabrosis,PMF)对呼吸功能的影响。方法于2014年1月—2015年5月从北京京煤集团有限责任公司煤工尘肺病患者中选取有PMF的患者41例为观察组(PMF组),另选同公司煤工尘肺病患者中无PMF的患者84例为对照组。观察呼吸频率和呼吸困难分级情况;肺功能各项指标、PaO_2(氧分压)、PaCO_2(二氧化碳分压)。应用SPSS 13.0统计软件包分析并处理数据。结果 PMF组与对照组呼吸频率比较,差异无统计学意义(P>0.05);呼吸困难分级比较,差异有统计学意义(P<0.05)。PMF组PaO_2明显低于对照组,而PaCO_2两组间差异无统计学意义。两组肺功能障碍类型均以混合性多见,其次是限制性。PMF组肺功能中重度损伤明显高于对照组,其差异有统计学意义(P<0.05)。PMF组FEV_(1.0)/FVC%、PEF、FEF 25%-75%、MEF 75%、MEF 50%、MEF 25%两组指标比较,差异有统计学意义(P<0.05)。结论 PMF可加重尘肺病患者的呼吸困难和肺功能损伤。
Objective To investigate the effects of progressive massive fabrosis (PMF) on respiratory function in coal worker’s pneumoconiosis. Methods From January 2014 to May 2015, 41 patients with PMF were selected as the observation group (PMF group) from coal miners with pneumoconiosis in Beijing Jingmei Group Co., Ltd., and the other coal miners with pneumoconiosis 84 patients without PMF as control group. Respiratory rate and dyspnea grading were observed. All indexes of pulmonary function, PaO 2 (oxygen partial pressure) and PaCO 2 (carbon dioxide partial pressure) were observed. SPSS 13.0 statistical package analysis and processing of data. Results There was no significant difference in respiratory rate between the PMF group and the control group (P> 0.05). The difference of respiratory dysfunctions was statistically significant (P <0.05). PaO_2 in PMF group was significantly lower than that in control group, while there was no significant difference between PaCO_2 and PaCO_2. Two types of pulmonary dysfunction were more common mixed, followed by the restriction. The moderate and severe lung injury in the PMF group was significantly higher than that in the control group, with significant difference (P <0.05). There were significant differences between the two groups in FEF1.0 / FVC%, PEF, FEF25% -75%, MEF75%, MEF50% and MEF25% in PMF group (P <0.05). Conclusions PMF can aggravate dyspnea and pulmonary function in patients with pneumoconiosis.