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目的探讨HPV与TCT检测在宫颈癌筛查中的应用价值分析。方法选择2013年3月—2015年3月行宫颈癌筛查的妇女为研究对象,其中197例患者行宫颈病理活检,均进行高危HPV及TCT检测。计数资料采用χ2检验,P<0.05为差异有统计学意义。结果 HPV的灵敏度为100.00%(73/73),TCT的灵敏度为12.33%(9/73),比较差异有统计学意义(χ2=113.95,P<0.05)。HPV的特异度为0,TCT的特异度为94.35%(117/124),比较差异有统计学意义(χ2=129.62,P<0.05)。HPV阳性预测值为37.06%(73/197),TCT阳性预测值为56.25%(9/16),比较差异无统计学意义(χ2=2.30,P>0.05)。HPV准确度为37.06%(73/197),TCT准确度为63.96%(126/197),比较差异有统计学意义(χ2=27.12,P<0.05)。结论 HPV与TCT检查应联合用于宫颈癌的筛查,可减少宫颈癌的漏诊率,达到早期治疗的目的,也可预防宫颈癌的发生。
Objective To investigate the value of HPV and TCT in the screening of cervical cancer. Methods From March 2013 to March 2015, women who underwent screening for cervical cancer were selected as the research objects. 197 patients underwent pathological biopsy of cervix, and high-risk HPV and TCT were detected. Count data using χ2 test, P <0.05 for the difference was statistically significant. Results The sensitivity of HPV was 100.00% (73/73). The sensitivity of TCT was 12.33% (9/73). The difference was statistically significant (χ2 = 113.95, P <0.05). The specificity of HPV was 0, and the specificity of TCT was 94.35% (117/124). The difference was statistically significant (χ2 = 129.62, P <0.05). The positive predictive value of HPV was 37.06% (73/197), and the positive predictive value of TCT was 56.25% (9/16). There was no significant difference between the two groups (χ2 = 2.30, P> 0.05). The accuracy of HPV was 37.06% (73/197), and the accuracy of TCT was 63.96% (126/197). The difference was statistically significant (χ2 = 27.12, P <0.05). Conclusion HPV and TCT should be combined for cervical cancer screening, which can reduce the misdiagnosis rate of cervical cancer and achieve the purpose of early treatment, but also prevent the occurrence of cervical cancer.