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为研究糖尿病合并高血压的发病机制，本文测定和比较了１９例血压正常的非胰岛素依赖型糖尿病（ＮＩＤＤＭ）病人，１１例单纯高血压病人，１２例ＮＩＤＤＭ合并高血压病人和１４例正常人的血浆内皮素－１（ＥＴ－１）和降钙素基因相关肽（ＣＧＲＰ）水平。结果发现：三组病人的ＥＴ－１水平均显著高于对照组，且呈依次上升趋势，而单纯高血压病组和糖尿病合并高血压组的ＣＧＲＰ水平均明显低于对照组，提示糖尿病合并高血压血浆ＥＴ－１升高，ＣＧＲＰ减低可能是糖尿病合并高血压的发病因素之一。
To investigate the pathogenesis of diabetes mellitus complicated with hypertension, we measured and compared 19 normotensive non-insulin dependent diabetes mellitus (NIDDM) patients, 11 hypertensive patients, 12 NIDDM patients with hypertension and 14 normal controls Plasma endothelin-1 (ET-1) and calcitonin gene-related peptide (CGRP) levels. The results showed that the levels of ET-1 in all three groups were significantly higher than those in the control group, and the levels of ET-1 in the hypertension group and the hypertensive diabetic group were significantly lower than those in the control group, suggesting that diabetes mellitus with high Blood pressure ET-1 increased, CGRP decreased may be one of the pathogenesis of diabetes complicated with hypertension.