论文部分内容阅读
目的探讨缬沙坦对原发性高血压患者的降压疗效及其对左室肥厚的影响。方法63例原发性高血压合并左室肥厚的患者,口服缬沙坦每天80~160mg,共6个月,观察缬沙坦的降压疗效以及其对左室肥厚的影响,并观察不良反应。结果63例患者经缬沙坦治疗后,收缩压、舒张压均有显著下降(P<0.01),左室舒张末期内径(LVDd)显著缩小(P<0.05),舒张末期室间隔厚度(IVSd)及舒张末期左室后壁厚度(IVPW d)也有显著减少(P<0.01)。结论缬沙坦治疗原发性高血压疗效确切,能够逆转左室肥厚。
Objective To investigate the antihypertensive effect of valsartan in patients with essential hypertension and its effect on left ventricular hypertrophy. Methods Sixty-three patients with essential hypertension with left ventricular hypertrophy were randomized to receive valsartan 80-80 mg daily for 6 months. The antihypertensive effect of valsartan and its effect on left ventricular hypertrophy were observed. Adverse reactions . Results After valsartan treatment, systolic pressure and diastolic pressure decreased significantly (P <0.01), left ventricular end diastolic diameter (LVDd) decreased significantly (P <0.05), and end diastolic interventricular septum thickness (IVSd) And left ventricular posterior wall thickness (IVPW d) also significantly decreased (P <0.01). Conclusion Valsartan is effective in treating essential hypertension and reversing left ventricular hypertrophy.