论文部分内容阅读
本实验研究发现绞股兰总甙、青春宝、有机锗和百臭健等药物均能降低NIH 小鼠血浆、肝、脑中过氧化脂质(LPO)的含量;提高肝、脑中超氧化物岐化酶(SOD)的活性.此外,绞股兰总甙、百臭健和有面锗等亦可降低NIH 小鼠皮肤羟脯氨酸的含量,提示这些药物具有抗氧化延缓衰老的作用。反之,青蒿琥酯(抗疟药)能提高小鼠血浆、肝、脑中LPO 的含量,同时也能增加皮肤羟脯氨酸的含量和抑制小鼠肝,脑中SOD 的活性,提示经常使用青蒿琥酯,具有加速体内氧化的作用,可能是一种促进组织衰老的药物.
In this experimental study, it was found that the drugs such as total psoriasis japonica, youthful treasure, organic peptone, and guanoxin can reduce the content of lipid peroxides (LPO) in plasma, liver, and brain of NIH mice; and improve superoxide in liver and brain. The activity of deuterase (SOD). In addition, the total glycosides of P. japonica, P. odoratum and P. olivaceus can also reduce the content of hydroxyproline in the skin of NIH mice, suggesting that these drugs have the effect of anti-oxidation and anti-aging. In contrast, artesunate (antimalarials) can increase LPO levels in plasma, liver, and brain of mice, but also increase the content of hydroxyproline in skin and inhibit the activity of SOD in liver and brain of mice. The use of artesunate has the effect of accelerating the oxidation in the body and may be a drug that promotes tissue senescence.