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细胞因子中的肿瘤坏死因子-α、白细胞介素-6在类风湿关节炎(RA)发病中的作用早已被人们认识。近期RA患者体内的一种神经内分泌激素促肾上腺皮质激素(ACTH)的异常表达亦逐渐被人们所认识。这两类物质相互影响而构成神经内分泌免疫调节网络。对此网络的研究将成为自身免疫疾病研究的新方向。
The role of tumor necrosis factor-alpha and interleukin-6 in cytokines in the pathogenesis of rheumatoid arthritis (RA) has long been recognized. Recent abnormal expression of a neuroendocrine hormone adrenocorticotrophic hormone (ACTH) in RA patients has gradually been recognized. These two types of substances interact to form the neuroendocrine immune regulatory network. Research on this network will become a new direction for the study of autoimmune diseases.