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A1c在血中的浓度取决于红细胞(RBC)寿命(平均120d)和血糖浓度,其形成率直接反映血糖浓度,因此代表了测定前8~12周的血糖平均值。1993年,DCCT研究突出了A1c在T1DM微血管并发症中的基础作用,在UKPDS研究中也观察到A1c与T2DM并发症有类似关系。A1c的优势还包括不要求患者空腹,不受急性因素,如应激或运动的影响等。最近,已有数个有影响的组织将A1c作为糖尿病诊断指标。
The concentration of A1c in the blood depends on the life span of the red blood cells (RBCs) (average 120 days) and the blood glucose level, and its formation rate directly reflects the blood glucose level, thus representing the average blood glucose level 8-12 weeks prior to the assay. In 1993, the DCCT study highlighted the underlying role of A1c in T1DM microvascular complications and a similar relationship between A1c and T2DM complications was also observed in the UKPDS study. The benefits of A1c include not requiring patients to have fasting without any acute factors such as stress or exercise. Recently, several influential organizations have used A1c as a diagnostic indicator of diabetes.