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在治疗高血压危象的药物中,甲基多巴奏效迟且药效变化无常;利血平使人感觉迟钝;肼苯哒嗪兴奋心脏,对人不利,在有急性左心衰竭趋势的患者尤甚,因而均不太适用。作者对23例高血压最少一个月的患者作用药后的血液动力学研究。第一组9例用氯苯甲噻二嗪(Diazoxide)300毫克一次静注;第二组7例予硝普钠(Sodium nitroprusside)60微克/毫升静脉滴入;第三组7例予三甲硫吩(Trimethaphan camphorate)1毫克/毫升静脉滴入。结果:第一组动脉压在头5分钟下降22％(P<0.0005),再过15分钟回升9％;心率在头5分钟增快31％(P<0.0005);
In the treatment of hypertensive crisis drugs, methyidopa and the erratic efficacy of erratic; reserpine make people feel insensitive; hydralazine excited heart, adverse to human, in patients with acute tendency of left heart failure In particular, they are not suitable. The author of 23 patients with hypertension for at least one month after the drug in patients with hemodynamic study. In the first group, 9 patients were given intravenous injection of Diazoxide 300 mg once. In the second group, 7 patients were treated with sodium nitroprusside 60 μg / mL intravenously. In the third group, 7 patients were given methyl thiosulfate Trimethaphan camphorate 1 mg / ml intravenously. Results: The first group of arterial pressure decreased 22% (P <0.0005) in the first 5 minutes and 9% in 15 minutes. The heart rate increased 31% (P <0.0005) in the first 5 minutes.