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目的 :研究健康志愿者单剂口服国产洛美沙星胶囊 40 0mg后的药物动力学特征。方法 :采用HPLC法测定血清和尿中药物浓度。结果 :该药在人体内的转运过程符合二室开放模型 ,血药峰浓度为 4.88mg·L-1,消除半衰期为 7.19h ,表观分布容积和AUC分别为 1.5 1L·kg-1和 5 1.0 3h·mg·L-1,总清除率为 2 .47ml·min-1·kg-1,48h尿药排泄率为 75 .7%。洛美沙星的人血清蛋白结合率为 16 .3%。结论 :本研究提示洛美沙星 40 0mg单剂口服后血和尿中可迅速达到有效抗菌浓度且持续时间较长
Objective: To study the pharmacokinetics of 40 mg single-dose domestic Lomefloxacin capsules in healthy volunteers. Methods: Serum and urine drug concentrations were determined by HPLC. Results: The drug transport in the human body was in accordance with the two-compartment open model. The peak plasma concentration was 4.88 mg · L-1 and the elimination half-life was 7.19 h. The apparent volume of distribution and AUC were 1.5 1 L · kg-1 and 5 1.0 3h · mg · L-1, the total clearance rate was 2.47ml · min-1 · kg-1, 48h urinary excretion rate was 75.7%. Lomefloxacin human serum protein binding rate of 16.3%. Conclusion: This study suggests that Lomefloxacin 40 0mg single oral dose of blood and urine can quickly reach the effective antibacterial concentration for a longer duration