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我们的前期研究发现心血管系统自身产生和分泌的调节肽参与运动性心肌肥大形成机制，但对心血管系统肽能神经纤维分泌的神经递质是否参与其机制尚不清楚。本实验采用放射免疫方法对运动性肥大心脏心肌局部降钙素基因相关肽（ｃａｌｃｉｔｏｎｉｎｇｅｎｅｒｅｌａｔｅｄｐｅｐｔｉｄｅ，ＣＧＲＰ）含量变化进行研究。结果表明，大鼠游泳运动１０周后，心系数比对照组增加３５％，心肌ＣＧＲＰ含量明显提高７０％，血浆ＣＧＲＰ含量提高４７％。这一结果提示，ＣＧＲＰ这一心血管神经调节肽在运动性心肌肥大形成中具有重要的调节作用，从已知ＣＧＲＰ作用机理推断，ＣＧＲＰ可能对运动性肥大心脏心肌收缩性的提高和肌球蛋白α重链的增加具有积极意义
Our previous study found that the regulatory peptides produced and secreted by the cardiovascular system are involved in the formation of exercise-induced cardiac hypertrophy. However, it remains unclear whether the neurotransmitters secreted by the cardiovascular system peptidergic nerve fibers are involved. In this study, radioimmunoassay was used to study the change of calcitonin gene related peptide (CGRP) in the myocardium of hypertrophic heart. The results showed that after 10 weeks of swimming, the heart rate increased by 35%, the myocardial CGRP content increased by 70% and the plasma CGRP content increased by 47%. This result suggests that CGRP, a cardiovascular neuromodulator, plays an important regulatory role in the development of exercise-induced cardiac hypertrophy. From the known mechanism of action of CGRP, it is concluded that CGRP may increase myocardial contractility and increase the activity of myosin α The increase in heavy chain has a positive meaning