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多年来一直应用加压素治疗门静脉高压,以控制食管静脉曲张破裂出血,但是在应用时发生血压升高,心排出量减少,冠状动脉血流量下降,组织供氧减少和心律不齐.有人在动物实验中应用加压素和某种血管扩张剂,从而明显减少了加压素对心血管的毒性反应,而仍能有效地使门静脉压下降达到治疗目的.本文对肝硬化门静脉高压患者用加压素和加用血管扩张剂的血液动力学作了对照观察和研究.作者对十二例慢性酒精中毒所致肝硬化门静脉高压病人进行了治疗,先静脉输注加压素0.4U/分,后加静脉输注硝普盐1μg/kg体重/分钟,每5分钟增加1μg/kg/分钟,直至血压达到基本水平.研究了加压素在两种不同情况下对全身、肺、肝和肾血液动力学以及血气的影响.门静脉压是通过肝静脉置三腔
Over the years has been the application of vasopressin in the treatment of portal hypertension to control esophageal variceal bleeding, but in the application of elevated blood pressure, cardiac output decreased, decreased coronary blood flow, decreased tissue oxygen supply and arrhythmia. Application of vasopressin and some vasodilators in animal experiments, which significantly reduces the vasopressin cardiovascular response, and still can effectively reduce the portal pressure for therapeutic purposes.In this paper, patients with cirrhosis and portal hypertension Hypertension and vasodilator plus hemodynamics were observed and studied. The author of 12 cases of chronic alcoholism caused cirrhosis of portal hypertension patients were treated with intravenous infusion of vasopressin 0.4U / min, Nitroprusside was then administered intravenously at 1 μg / kg body weight / minute and 1 μg / kg / minute every 5 minutes until blood pressure reached a basal level. The effects of vasopressin on body, lung, liver and kidney were investigated in two different situations Hemodynamic and blood gas effects. Portal venous pressure is through the hepatic vein in the third chamber