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目的评价序贯机械通气对急性有机磷中毒并中间综合征(IMS)治疗效果。方法选取2006年10~2008年10月收治的42例IMS患者,随机分成序贯组和对照组各21例,对照组单纯给予机械通气,序贯组给予有创-无创序贯机械通气。动态观察两组患者呼吸机相关肺炎(VAP)发生率、有创机械通气时间、总机械通气时间(MV时间)、住ICU时间、总住院时间及总住院费用等情况。结果序贯组VAP发生率、有创机械通气时间、住ICU时间、总住院时间及总住院费用明显低于对照组(P<0.05)。结论有创-无创序贯机械通气治疗急性重度有机磷中毒合并中间综合征疗效肯定而又安全可靠,值得在临床推用。
Objective To evaluate the effect of sequential mechanical ventilation on acute organophosphate poisoning and intermediate syndrome (IMS). Methods Forty-two patients with IMS who were admitted to our hospital from October 2006 to October 2008 were randomly divided into sequential group and control group, 21 cases in each group. The control group was given mechanical ventilation alone, and the sequential group was given invasive-noninvasive sequential mechanical ventilation. The incidences of ventilator-associated pneumonia (VAP), invasive mechanical ventilation (MV), total mechanical ventilation (MV), ICU stay, total hospital stay and total hospital stay were dynamically observed in both groups. Results The incidence of VAP, invasive mechanical ventilation, ICU stay, total hospital stay and total hospital stay in sequential group were significantly lower than those in control group (P <0.05). Conclusions The invasive and noninvasive sequential mechanical ventilation is effective and reliable in the treatment of acute severe organophosphate poisoning complicated with middle syndrome, which is worthy of clinical application.