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目的观察参苓白术散加减治疗妇科恶性肿瘤化疗后白细胞(WBC)下降的临床疗效及其对患者生活质量的影响。方法将84例妇科恶性肿瘤化疗后WBC下降患者随机分为治疗组与对照组,每组42例,对照组患者给予利血生与鲨肝醇进行常规治疗;治疗组在对照组基础上给予参苓白术散加减,两组均以4周为1个疗程。2个疗程后评定疗效并观察两组治疗前后外周血细胞包括WBC、红细胞(RBC)、血红蛋白(HGB)、血小板(PLT)、淋巴细胞(LYM)、中性粒细胞(GRAN)、血小板比率(PLT%)、淋巴细胞比率(LYM%)、中值细胞比率(MON%)、中性细胞比率(GRAN%)等指标的变化及Spitzer生存质量指数评定量表评分(Spitzer评分)、癌症康复评价简表(CARES-SF评分)情况。结果两组患者治疗后WBC、RBC、HGB、PLT、LYM、GRAN、PLT%、LYM%、MON%、GRAN%等各项指标与治疗前比较均有明显改善(P<0.05);治疗后治疗组WBC、HGB、LYM、MON%、GRAN%改善程度明显优于对照组(P<0.05)。治疗组总有效率为90.48%,对照组总有效率为73.81%,治疗组明显优于对照组(P<0.05)。与治疗前比较,两组治疗后Spitzer评分明显提高(P<0.05)、治疗组治疗后CARES-SF评分明显降低(P<0.05);与对照组治疗后比较,治疗组Spitzer评分、CARES-SF评分差异均有统计学意义(P<0.05)。结论参苓白术散加减治疗妇科恶性肿瘤化疗后WBC下降疗效显著,可明显提高患者生活质量。
Objective To observe the clinical efficacy of Shenling Baizhu San on the reduction of white blood cells (WBC) after gynecological malignant tumor chemotherapy and its effect on quality of life of patients. Methods Eighty-four patients with malignant gynecological malignancy after chemotherapy were randomly divided into treatment group and control group, with 42 cases in each group. Patients in control group were given routine treatment of reserpine and batyl alcohol. The treatment group was given control group Lingbai San addition and subtraction, two groups were 4 weeks for a course of treatment. After 2 courses of treatment, the curative effect was evaluated and the changes of peripheral blood cells including WBC, RBC, HGB, PLT, LYM, GRAN, PLT %), Lymphocyte ratio (LYM%), median cell ratio (MON%), neutral cell ratio (GRAN%) and other indicators and Spitzer quality of life index scale (Spitzer score), cancer rehabilitation assessment of Jane Table (CARES-SF score) situation. Results After treatment, the indexes of WBC, RBC, HGB, PLT, LYM, GRAN, PLT%, LYM%, MON% and GRAN% in both groups were significantly improved compared with those before treatment (P < The improvement of WBC, HGB, LYM, MON% and GRAN% was significantly better than that of the control group (P <0.05). The total effective rate was 90.48% in the treatment group and 73.81% in the control group, which was significantly better in the treatment group than in the control group (P <0.05). The Spitzer score was significantly higher in both groups after treatment (P <0.05), and the CARES-SF score was significantly lower in the two groups after treatment (P <0.05). Compared with the control group, Spitzer score, CARES-SF There was significant difference between the scores (P <0.05). Conclusion Shenling Baizhu San reduction treatment of gynecologic malignancies WBC decreased significantly after chemotherapy, can significantly improve the quality of life of patients.